A sea sponge metabolite with diverse biological activities; induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner from 0.25-0.5 μM; blocks EGF-induced endocytosis of EGFR and EGF-dependent cell proliferation in MCF-7 cells; inhibits BAE cell proliferation and cord formation in a Matrigel™ assay; inhibits angiogenesis in a CAM assay from 1.5-3 nmol per egg; has antibacterial activity against Gram-positive bacteria; inhibits HIV-1 replication (IC50 = 14.6 μM)

(+)-Aeroplysinin-1 – 100 µg

Brand:
Cayman
CAS:
28656-91-9
Storage:
-20
UN-No:
Non-Hazardous - /

(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities.{42142} (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM.{42143} It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay.{42144} It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC50 = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.{42145}  

 

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Description

A sea sponge metabolite with diverse biological activities; induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner from 0.25-0.5 μM; blocks EGF-induced endocytosis of EGFR and EGF-dependent cell proliferation in MCF-7 cells; inhibits BAE cell proliferation and cord formation in a Matrigel™ assay; inhibits angiogenesis in a CAM assay from 1.5-3 nmol per egg; has antibacterial activity against Gram-positive bacteria; inhibits HIV-1 replication (IC50 = 14.6 μM) ,

Formal name: (1S,6R)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonitrile

Synonyms:  NSC 170364

Molecular weight: 339

CAS: 28656-91-9

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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