An inhibitor of p75NTR- and NRAGE-induced apoptosis; inhibits JNK signaling

AEG 3482 – 25 mg

Brand:
Cayman
CAS:
63735-71-7
Storage:
-20
UN-No:
Non-Hazardous - /

AEG 3482 is an inhibitor of p75NTR- and NRAGE-induced apoptosis.{49017} It inhibits JNK signaling, caspase-3 cleavage, and cell death induced by the p75 neurotrophin receptor (p75NTR) or the p75NTR-interacting protein NRAGE in PC12rtTA cells in a concentration-dependent manner. AEG 3482 inhibits cell death induced by withdrawal of nerve growth factor (NGF) in rat SCG neurons (EC50 = ~20 μM). It also increases Hsp70 and Hsp25 levels in mouse embryonic fibroblasts (MEFs) in an HSF1-dependent manner and binds to recombinant Hsp90.  

 

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SKU: 26213 - 25 mg Category:

Description

An inhibitor of p75NTR- and NRAGE-induced apoptosis; inhibits JNK signaling, caspase-3 cleavage, and cell death induced by p75NTR or NRAGE in PC12rtTA cells in a concentration-dependent manner; inhibits cell death induced by withdrawal of NGF in rat SCG neurons (EC50 = ~20 μM); increases Hsp70 and Hsp25 levels in MEFs in an HSF1-dependent manner; binds recombinant Hsp90

Formal name: 6-phenyl-imidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

Synonyms: 

Molecular weight: 280.3

CAS: 63735-71-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cellular Chaperones||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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