A δ-opioid receptor agonist (Ki = 0.84 nM); selective for δ-opioid receptors over μ-opioid and κ-opioid receptors at 10 μM; completely reverses CFA-induced mechanical hyperalgesia in rats at 3 mg/kg; decreases immobility time in the forced swim test in rats

ADL5859 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
850173-95-4
Storage:
-20
UN-No:
- /

ADL5859 is a δ-opioid receptor agonist (Ki = 0.84 nM).{45386} It is selective for δ-opioid receptors over μ-opioid and κ-opioid receptors exhibiting 32 and 37% inhibition, respectively, in radioligand binding assays when used at a concentration of 10 μM. ADL5859 (3 mg/kg) completely reverses mechanical hyperalgesia induced by complete Freund’s adjuvant (CFA) in rats. It also decreases immobility time in the forced swim test in rats, indicating antidepressant-like activity.  

 

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SKU: 27796 - 10 mg Category:

Description

A δ-opioid receptor agonist (Ki = 0.84 nM); selective for δ-opioid receptors over μ-opioid and κ-opioid receptors at 10 μM; completely reverses CFA-induced mechanical hyperalgesia in rats at 3 mg/kg; decreases immobility time in the forced swim test in rats

Formal name: N,N-diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4′-piperidin]-4-yl)-benzamide, monohydrochloride

Synonyms: 

Molecular weight: 429

CAS: 850173-95-4

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Neuroscience|Behavioral Neuroscience|Depression||Research Area|Neuroscience|Pain Research

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