A derivative of ionidamine; inhibits human spermatozoa capacitance potentially by blocking chloride channels; tightens the Sertoli cell permeability barrier dose-dependently in vitro; increases testin expression in adult rat testes within one day and depletes spermatids and spermatocytes when administered at a dose of 25 or 50 mg/kg; reversibly induces infertility of male rats within 3-7 weeks

Adjudin – 1 mg

Brand:
Cayman
CAS:
252025-52-8
Storage:
-20
UN-No:
Non-Hazardous - /

Adjudin is a derivative of ionidamine that inhibits human spermatozoa capacitance, potentially by blocking chloride channels.{40350} It inhibits spermatozoa hyperactivated motility and the acrosome reaction and prevents sperm-egg fusion in zona-free hamster eggs. It also disrupts Sertoli-germ cell junctions by increasing tight junction and basal ectoplasmic specialization protein levels, which tightens the cell permeability barrier dose-dependently in vitro.{40351} Adjudin (25 and 50 mg/kg) increases testin expression in adult rat testes within one day and depletes spermatids and spermatocytes within 14 days.{40349} Under various dosing parameters, adjudin reversibly induces infertility of male rats within 3-7 weeks, which lasts 4-14 weeks, without affecting serum levels of luteinizing hormone (LH), follicle stimulating hormone (FSH), or testosterone. Adjudin also decreases proliferation of SGC-7901, MDA-MB-231, Smmc-7721, and MIA Paca-2 cells (IC50s = 58, 13.8, 72.3, and 52.7 µM, respectively) and induces apoptosis via the caspase-3-dependent pathway.{40352}  

 

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SKU: 22939 - 1 mg Category:

Description

A derivative of ionidamine; inhibits human spermatozoa capacitance potentially by blocking chloride channels; tightens the Sertoli cell permeability barrier dose-dependently in vitro; increases testin expression in adult rat testes within one day and depletes spermatids and spermatocytes when administered at a dose of 25 or 50 mg/kg; reversibly induces infertility of male rats within 3-7 weeks, which lasts 4-14 weeks; decreases proliferation of SGC-7901, MDA-MB-231, Smmc-7721, and MIA Paca-2 cells (IC50s = 58, 13.8, 72.3, and 52.7 µM, respectively)

Formal name: 1-[(2,4-dichlorophenyl)methyl]-1H-indazole-3-carboxylic acid, hydrazide

Synonyms:  AF-2364

Molecular weight: 335.2

CAS: 252025-52-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Reproductive Biology

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