An orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 (KDs = 1.8 and 3.1 µM

AdipoRon – 10 mg

Brand:
Cayman
CAS:
924416-43-3
Storage:
-20
UN-No:
Non-Hazardous - /

Adiponectin expressed by adipocytes exerts antidiabetic effects by binding to adiponectin receptor (AdipoR)1, which activates AMPK pathways, and AdipoR2, which activates PPARα pathways. AdipoRon is an orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 with KD values of 1.8 and 3.1 µM, respectively.{25721} At 50 mg/kg, it acts similarly to adiponectin, activating AMPK and PPARα pathways and reducing insulin resistance and glucose intolerance in wild type mice fed a high-fat diet and in genetically obese db/db mice.{25721}  

 

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Description

An orally active small molecule AdipoR agonist that binds AdipoR1 and AdipoR2 (KDs = 1.8 and 3.1 µM, respectively); at 50 mg/kg, activates AMPK and PPARα pathways and reduces insulin resistance and glucose intolerance in wild type mice fed a high-fat diet as well as in genetically obese db/db mice

Formal name: 2-(4-benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]-acetamide

Synonyms: 

Molecular weight: 428.5

CAS: 924416-43-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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