Description
An atypical retinoid; does not induce RARα or RAR-mediated transcription in a luciferase assay; inhibits proliferation of mutant p53-containing DU145 prostate, A431 cervical, and Me665/2/21 melanoma cancer cells (IC50s = 0.1, 0.25, and 0.25 µM, respectively) and wild-type p53-containing LNCaP prostate, H460 non-small cell lung, and HCT116 colon cancer cells (IC50s = 0.12, 0.19, and 0.32 µM, respectively); induces DNA damage in wild-type p53-containing IGROV-1 cells and apoptosis in IGROV-1 and DU145 cells; reduces tumor burden and increases survival in a mouse model of CML at 15 mg/kg per day
Formal name: (2E)-3-(4′-hydroxy-3′-tricyclo[3.3.1.13,7]dec-1-yl[1,1′-biphenyl]-4-yl)-2-propenoic acid
Synonyms: ST1926
Molecular weight: 374.5
CAS: 496868-77-0
Purity: ≥98%
Formulation: A crystalline solid
