An inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1)

ADAMTS-5 Inhibitor – 1 mg

Brand:
Cayman
CAS:
929634-33-3
Storage:
-20
UN-No:
Non-Hazardous - /

A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) is an aggrecanase in that it cleaves aggrecan, a major proteoglycan in cartilage. While it has key roles in cartilage destruction associated with osteoarthritis, ADAMTS-5 is also involved in other pathways, including neurological processes.{28337,28336} ADAMTS-5 Inhibitor is an inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1).{28335,28334}  

 

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Description

An inhibitor of ADAMTS-5 (aggrecanase-2; IC50 = 1.1 µM) with 40-fold selectivity over ADAMTS-4 (aggrecanase-1)

Formal name: 5-[[5-[[(4-chlorophenyl)methyl]thio]-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methylene]-2-thioxo-4-thiazolidinone

Synonyms:  A Disintegrin and Metalloproteinase with Thrombospondin Motifs 5 Inhibitor

Molecular weight: 449.9

CAS: 929634-33-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area

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