An internal standard for the quantification of acyclovir by GC- or LC-MS

Acyclovir-d4 – 1 mg

Brand:
Cayman
CAS:
1185179-33-2
Storage:
-20
UN-No:
Non-Hazardous - /

Acyclovir-d4 is intended for use as an internal standard for the quantification of acyclovir (Item No. 14160) by GC- or LC-MS. Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).{22178} It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.{22179} Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.{48054}  

 

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SKU: 26272 - 1 mg Category:

Description

An internal standard for the quantification of acyclovir by GC- or LC-MS ,

Formal name: 2-amino-9-((2-hydroxyethoxy-1,1,2,2-d4)methyl)-1,9-dihydro-6H-purin-6-one

Synonyms:  ACV-d4

Molecular weight: 229.2

CAS: 1185179-33-2

Purity: ≥99% deuterated forms (d0-d4)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Antivirals|DNA & RNA Polymerase Inhibitors||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Chicken Pox & Shingles||Research Area|Infectious Disease|Viral Diseases|Epstein-Barr||Research Area|Infectious Disease|Viral Diseases|HSV

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