An HDAC6 inhibitor (IC50 = 0.0075 µM); selective for HDAC6 over HDAC1

ACY-775 – 1 mg

Brand:
Cayman
CAS:
1375466-18-4
Storage:
-20
UN-No:
Non-Hazardous - /

ACY-775 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.0075 µM).{47573} It is selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively). ACY-775 (2.5 µM) increases α-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells. It increases the distance traveled in the center of the open field test and decreases immobility time in the tail suspension test, indicating anxiolytic- and antidepressant-like activities, respectively, in mice when administered at a dose of 50 mg/kg.  

 

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SKU: 29198 - 1 mg Category:

Description

An HDAC6 inhibitor (IC50 = 0.0075 µM); selective for HDAC6 over HDAC1, HDAC2, and HDAC3 (IC50s = 2.1, 2.5, and 11.2 µM, respectively); increases α-tubulin acetylation at lysine 40 in RN46A-B14 serotonergic cells at 2.5 µM; increases the distance traveled in the center of the open field test and decreases immobility time in the tail suspension test in mice at 50 mg/kg

Formal name: 2-[[1-(3-fluorophenyl)cyclohexyl]amino]-N-hydroxy-5-pyrimidinecarboxamide

Synonyms: 

Molecular weight: 330.4

CAS: 1375466-18-4

Purity: ≥95%

Formulation: A solid

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