A cyclic polypeptide-containing anticancer antibiotic that binds to DNA and blocks transcription by interfering with RNA synthesis; ~10 nM promotes cell death in a variety of tumors

Actinomycin D – 10 mg

Brand:
Cayman
CAS:
50-76-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Actinomycin D is a cyclic polypeptide-containing antibiotic that binds to DNA and blocks transcription. It binds to pre-melted double-stranded DNA in transcription bubbles and once bound is slow to dissociate.{21521,21519} DNA in transcriptionally hyperactive cancer cells efficiently and rapidly bind actinomycin D at low concentrations (~10 nM), which interferes with RNA synthesis and ultimately leads to cell death.{21521,21520} Actinomycin D is widely used as an anticancer agent for treating a variety of tumors and along with its fluorescent derivative, 7-aminoactinomycin D (Item No. 11397) has become a useful tool in biochemistry and molecular biology research as a marker for DNA.  

 

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SKU: 11421 - 10 mg Category:

Description

A cyclic polypeptide-containing anticancer antibiotic that binds to DNA and blocks transcription by interfering with RNA synthesis; ~10 nM promotes cell death in a variety of tumors

Formal name: 2-amino-N,N’-bis(hexadecahydro-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxo-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl)-4,6-dimethyl-3-oxo-3H-phenoxazine-1,9-dicarboxamide

Synonyms:  Cosmegen|Dactinomycin|Meractinomycin|NCI C04682|NSC 3053|Oncostatin K

Molecular weight: 1,255.50

CAS: 50-76-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair||Research Area|Epigenetics, Transcription, & Translation|RNA, DNA, & Protein Synthesis

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