An anthracycline with antibiotic and anticancer activities; active against B. subtilis

Aclarubicin – 100 µg

Brand:
Cayman
CAS:
57576-44-0
Storage:
-20
UN-No:
De Minimis - 3462 / 6.1

Aclarubicin is an anthracycline originally isolated from Streptomyces and has antibiotic and anticancer activities.{52752} It is active against B. subtilis, B. cereus, S. aureus, M. smegmatis, S. pyogenes, and S. faecalis (MICs = 50 = 0.12 μg/ml) and increases survival in an L1210 murine leukemia model when administered at a dose of 1.5 mg/kg per day.{52752}  

 

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Description

An anthracycline with antibiotic and anticancer activities; active against B. subtilis, B. cereus, S. aureus, M. smegmatis, S. pyogenes, and S. faecalis (MICs = 50 = 0.12 μg/ml); a DNA intercalating agent, topoisomerase I poison, and an inhibitor of topoisomerase II catalytic activity; increases survival in an L1210 murine leukemia model at 1.5 mg/kg per day

Formal name: (1R,2R,4S)-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,6S)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-α-L-lyxo-hexopyranosyl]-3-(dimethylamino)-α-L-lyxo-hexopyranosyl]oxy]-1-naphthacenecarboxylic acid, methyl ester

Synonyms:  NSC 208734

Molecular weight: 811.9

CAS: 57576-44-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|DNA Damage and Repair|DNA Intercalating Agents||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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