A glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase

Acivicin – 10 mg

Brand:
Cayman
CAS:
42228-92-2
Storage:
-20
UN-No:
Non-Hazardous - /

Acivicin is a glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively).{21903,21899} It also reversibly inhibits γ-glutamyl transpeptidase.{21902,21901} Acividin has been used to elucidate aspects of glutathione metabolism and has known anti-tumorigenic activity.{21898,21900,21899,21897}  

 

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Description

A glutamine analog that irreversibly inhibits glutamine-dependent amidotransferases involved in nucleotide and amino acid biosynthesis (Kis = 10 and 560 μM for anthranilate synthase and glutamate synthase, respectively); reversibly inhibits γ-glutamyl transpeptidase

Formal name: αS-amino-3-chloro-4,5S-dihydro-5-isoxazoleacetic acid

Synonyms:  Antibiotic AT-125|NSC 163501|U 42126

Molecular weight: 178.6

CAS: 42228-92-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cancer

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