Description
A retinoid and an active metabolite of the retinoid etretinate that has antiproliferative activities; binds to CRABP-1 and CRABP-II (Kds = 3 and 15 nM, respectively, for the mouse recombinant proteins) but has low affinity for human recombinant retinoic acid receptor-retinoid X receptor (RAR-RXR) heterocomplexes; inhibits proliferation (IC50 = 6.6 µM) and suppresses TNF-α- and IFN-γ-induced protein levels of STAT1, NF-ĸB, and RANTES in HaCaT keratinocytes when used at 50 µM; inhibits proliferation of HL-60, SCC4, SCC15, and A431, but not MCF-7, cancer cells, at 30 µM; decreases the severity of psoriatic-like skin lesions in K14-VEGF transgenic mice (20 µg per mouse)
Formal name: (2E,4E,6E,8E)-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid
Synonyms: all-trans Acitretin|Ro 10-1670|Ro 10-1670/000
Molecular weight: 326.4
CAS: 55079-83-9
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Lipids|Prenol Lipids||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Cell Signaling|NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cancer|Transcription Factors|STATs||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Lipid Biochemistry|Prenol Lipids
