An antilipolytic agent; inhibits lipolysis induced by noradrenaline and theophylline in rat epididymal adipocytes at 1 μM; decreases plasma free fatty acid levels in rats at 3 and 12 mg/kg; reduces plasma fatty acid concentration

Acipimox – 1 g

Brand:
Cayman
CAS:
51037-30-0
Storage:
-20
UN-No:
Non-Hazardous - /

Acipimox is an antilipolytic agent.{36963} It inhibits lipolysis induced by noradrenaline and theophylline in rat epididymal adipocytes when used at a concentration of 1 μM. Acipimox (3 and 12 mg/kg, p.o.) decreases plasma free fatty acid levels in rats. It reduces plasma fatty acid concentration, the number of atherosclerotic plaques, and matrixmetalloproteinase-2 (MMP-2) activity in ApoE-/- mice fed a palmitate-rich diet.{36965} Acipimox also reduces fasting blood glucose and plasma insulin levels as well as plasma free fatty acid and triglyceride levels in a rat model of diabetes induced by streptozotocin (Item No. 13104).{36964} Formulations containing acipimox have been used in the treatment of hyperlipidemia in patients with non-insulin-dependent diabetes.  

 

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SKU: 26090 - 1 g Category:

Description

An antilipolytic agent; inhibits lipolysis induced by noradrenaline and theophylline in rat epididymal adipocytes at 1 μM; decreases plasma free fatty acid levels in rats at 3 and 12 mg/kg; reduces plasma fatty acid concentration, the number of atherosclerotic plaques, and MMP-2 activity in ApoE-/- mice fed a palmitate-rich diet; reduces fasting blood glucose and plasma insulin levels as well as plasma free fatty acid and triglyceride levels in a rat model of streptozotocin-induced diabetes

Formal name: 5-methyl-2-pyrazinecarboxylic acid, 4-oxide

Synonyms: 

Molecular weight: 154.1

CAS: 51037-30-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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