Description
An inhibitor of IKKβ and IKKα (IC50s = 8.5 and 250 nM, respectively); selective for IKKβ and IKKα over IKKγ, Syk, and MKK4 (IC50s = >20 µM for all); reduces the constitutive phosphorylation of IκBα and NF-κB p65 in U266 and NCU-MM-2 cells at 50 µM; prevents TNF-α-induced activation of NF-κB in U266 cells at 0.1 µM; inhibits the growth of U266, NCU-MM-2, ILKM2, and BJAB cells (IC50s = 18.3, 27.6, 34.6, and 17.6 µM, respectively); prevents TNF-α-induced HIV-1 replication in latently HIV-1-infected OM10.1 cells (EC50 = 0.56 µM); prevents PMA-and imiquimod-induced skin inflammation in mice at 5 mg/kg
Formal name: 2-amino-6-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-4-(4-piperidinyl)-3-pyridinecarbonitrile
Synonyms:
Molecular weight: 364.4
CAS: 406208-42-2
Purity: ≥98%
Formulation: A solid
Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cancer|Transcription Factors|NF-κB||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS
