An inhibitor of MAIT cell activation; dose-dependently increases the surface expression of Mr1 without activating MAIT cells when used at concentrations ranging from 0.23-15 µM; a degradation product of folic acid; a precursor in the synthesis of 2’-hydroxy-7

Acetyl-6-formylpterin – 25 mg

Brand:
Cayman
CAS:
29769-49-1
Storage:
-20
UN-No:
Non-Hazardous - /

Acetyl-6-formylpterin is an inhibitor of mucosal-associated invariant T (MAIT) cell activation.{40442} It dose-dependently increases the surface expression of MHC-related 1 (Mr1) in WT3 cells overexpressing Mr1 (WT3-m) following incubation with E. coli but does not activate MAIT cells cocultured with WT3-m cells when used at concentrations ranging from 0.23-15 µM. Acetyl-6-formylpterin is also a degradation product of folic acid (Item No. 20515) and a precursor in the synthesis of 2’-hydroxy-7,8-dihydrofolate, which is a metabolite of para-aminosalicylic acid (PAS) in M. tuberculosis.{40441}  

 

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SKU: 23303 - 25 mg Category:

Description

An inhibitor of MAIT cell activation; dose-dependently increases the surface expression of Mr1 without activating MAIT cells when used at concentrations ranging from 0.23-15 µM; a degradation product of folic acid; a precursor in the synthesis of 2’-hydroxy-7,8-dihydrofolate

Formal name: N-(6-formyl-3,4-dihydro-4-oxo-2-pteridinyl)-acetamide

Synonyms:  2-Acetamido-6-formylpteridin-4-one|Ac-6-FP|NSC 129965

Molecular weight: 233.2

CAS: 29769-49-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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