A muscarinic agonist; decreases heart rate and blood pressure and increases the airway pressure time index in a dose-dependent manner in wild-type mice

Acetyl-β-methylcholine (chloride) – 25 g

Brand:
Cayman
CAS:
62-51-1
Storage:
-20
UN-No:
Non-Hazardous - /

Acetyl-β-methylcholine is a muscarinic (M) receptor agonist.{36128} In wild-type mice, acetyl-β-methylcholine decreases heart rate and blood pressure and increases the airway pressure time index, a measure of bronchoconstriction, in a dose-dependent manner. Cardiac and pulmonary responses are abolished in M2 and M3 knockout mice, respectively, suggesting that acetyl-β-methylcholine acts on cardiac M2 and pulmonary M3 receptors. Formulations containing acetyl-β-methylcholine have been used to diagnose asthma and to monitor response to asthma therapies.{36129}  

 

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SKU: 23092 - 25 g Category:

Description

A muscarinic agonist; decreases heart rate and blood pressure and increases the airway pressure time index in a dose-dependent manner in wild-type mice

Formal name: 2-(acetyloxy)-N,N,N-trimethyl-1-propanaminium, monochloride

Synonyms:  Methacholine

Molecular weight: 195.7

CAS: 62-51-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Heart|Arrhythmia

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