An irreversible urease inhibitor; inhibits the growth of struvite crystals in artificial urine; inhibits the growth of H. pylori in vitro (MICs = 200 and 400 mg/L for various isolates); chronic administration reduces urine urease activity

Acetohydroxamic Acid – 25 g

Brand:
Cayman
CAS:
546-88-3
Storage:
-20
UN-No:
Non-Hazardous - /

Acetohydroxamic acid (AHA) is an irreversible inhibitor of urease and a derivative of hydroxyurea (Item No. 23725).{40705} It inhibits the growth of struvite crystals produced by P. mirabilis in artificial urine and the growth of H. pylori in vitro (MICs = 200 and 400 mg/L for various isolates of H. pylori).{40706,40707} Chronic AHA administration in dogs dose-dependently reduces urine urease activity, pH, and crystalluria and inhibits growth of bladder stones.{40708} It also decreases gastritis, gastric lesions, and bacterial infection rates in Mongolian gerbils when administered at 2,500 ppm/animal following H. pylori infection.{40709} Formulations containing AHA have been used in the treatment of urinary tract infections.  

 

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SKU: 23979 - 25 g Category:

Description

An irreversible urease inhibitor; inhibits the growth of struvite crystals in artificial urine; inhibits the growth of H. pylori in vitro (MICs = 200 and 400 mg/L for various isolates); chronic administration reduces urine urease activity, pH, and crystalluria and inhibits growth of bladder stones in dogs; decreases gastritis, gastric lesions, and bacterial infection rats in gerbils (2,500 ppm/animal) following , H. pylori infection

Formal name: N-hydroxy-acetamide

Synonyms:  AHA|NSC 176136|NSC 408425|NSC 5073

Molecular weight: 75.1

CAS: 546-88-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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