A phenothiazine antipsychotic and a dopamine receptor antagonist; binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits acetylcholine-induceed contractions of guinea pig ileum (IC50 = 840 nM); inhibits morphine-induced vomiting in dogs; inhibits development of a conditioned avoidance response

Acepromazine (maleate) – 250 mg

Brand:
Cayman
CAS:
3598-37-6
Storage:
-20
UN-No:
Non-Hazardous - /

Acepromazine is a phenothiazine antipsychotic, analog of chlorpromazine (Item No. 16129), and a dopamine receptor antagonist.{46374} It also binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits contractions of guinea pig ileum induced by acetylcholine (Item No. 23829; IC50 = 840 nM).{46375} Acepromazine inhibits morphine-induced vomiting in dogs.{46376} It also inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED50s = 0.98, 3.1, and 17 mg/kg, respectively).{46377} Formulations containing acepromazine have been used as tranquilizers and anesthetics premedicant in small and large animal veterinary care.  

 

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Description

A phenothiazine antipsychotic and a dopamine receptor antagonist; binds to muscarinic receptors in rat brain (IC50 = 350 nM) and inhibits acetylcholine-induceed contractions of guinea pig ileum (IC50 = 840 nM); inhibits morphine-induced vomiting in dogs; inhibits development of a conditioned avoidance response, unconditioned escape response, and catalepsy in rats (ED50s = 0.98, 3.1, and 17 mg/kg, respectively)

Formal name: 1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-ethanone, mono-2Z-butenedioate

Synonyms:  ,Acetylpromazine|ACE|NSC 264522

Molecular weight: 442.5

CAS: 3598-37-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Neuroscience|Behavioral Neuroscience|Schizophrenia & Psychosis

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