An NSAID and prodrug of indomethacin; reduces zymosan-induced TXB2 and PGE2 production in isolated rat whole blood and stomach

Acemetacin – 1 g

Brand:
Cayman
CAS:
53164-05-9
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Acemetacin is a non-steroidal anti-inflammatory drug (NSAID) and a prodrug form of indomethacin (Item No. 70270).{48888} It reduces zymosan-induced thromboxane B2 (TXB2; Item No. 19030) and prostaglandin E2 (PGE2; Item No. 14010) production in isolated rat whole blood and stomach, respectively, when administered at doses ranging from 2.7 to 83.8 µmol/kg. Acemetacin (1.3, 2.5, and 10 mg/kg) also reduces carrageenan-induced PGE2 production in rat synovial membranes.{48889} It decreases leukocyte infiltration in the exudate in a rat model of zymosan-induced air pouch inflammation when administered at doses of 27.9 and 83.8 µmol/kg.{48888}  

 

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Description

An NSAID and prodrug of indomethacin; reduces zymosan-induced TXB2 and PGE2 production in isolated rat whole blood and stomach, respectively, from 2.7-83.3 µmol/kg; reduces carrageenan-induced PGE2 production in rat synovial membranes at 1.3, 2.5, and 10 mg/kg; decreases leukocyte infiltration in the exudate in a rat model of zymosan-induced air pouch inflammation at 27.9 and 83.8 µmol/kg

Formal name: 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid, carboxymethyl ester

Synonyms: 

Molecular weight: 415.8

CAS: 53164-05-9

Purity: ≥98%

Formulation: A crystalline solid

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