An internal standard for the quantification of acamprosate by GC- or LC-MS

Acamprosate-d3 (calcium salt) – 500 µg

Brand:
Cayman
CAS:
1225580-94-8
Storage:
-20
UN-No:
Non-Hazardous - /

Acamprosate-d3 is intended for use as an internal standard for the quantification of acamprosate (Item No. 23899) by GC- or LC-MS. Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; Item No. 20701).{36372} Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 µM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release.{36373,36371,36374} It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors.{36374} Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline (Item No. 11727). Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.  

 

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SKU: 26780 - 500 µg Category:

Description

An internal standard for the quantification of acamprosate by GC- or LC-MS

Formal name: 3-(acetyl-2,2,2-d3-amino)-1-propanesulfonic acid, hemicalcium salt (2:1)

Synonyms:  N-acetyl Homotaurinate-d3|N-acetyl Homotaurine-d3

Molecular weight: 203.3

CAS: 1225580-94-8

Purity: ≥99% deuterated forms (d1-d3)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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