An irreversible BTK inhibitor; dose-dependently inhibits B cell receptor signaling in primary CLL cells

Acalabrutinib – 10 mg

Brand:
Cayman
CAS:
1420477-60-6
Storage:
-20
UN-No:
Non-Hazardous - /

Acalabrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase (BTK). It can dose-dependently inhibit B cell receptor signaling in primary chronic lymphocytic leukemia cells.{32705} In kinase-inhibition assays, acalabrutinib was more selective than ibrutinib (Item No. 16274) for inhibiting BTK and did not inhibit EGFR, Itk, or Txk signaling.{32705}  

 

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Description

An irreversible BTK inhibitor; dose-dependently inhibits B cell receptor signaling in primary CLL cells

Formal name: 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-benzamide

Synonyms:  ACP-196

Molecular weight: 465.5

CAS: 1420477-60-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Tec Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Tec Family Signaling

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