A TRPC5 inhibitor (IC50 = 14.7 µM); selective for TRPC5 over TRPC4 and TRPC6 at concentrations up to 100 and 30 µM

AC1903 – 5 mg

Brand:
Cayman
CAS:
831234-13-0
Storage:
-20
UN-No:
Non-Hazardous - /

AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5; IC50 = 14.7 µM).{40587} It is selective for TRPC5 over TRPC4 and TRPC6 at concentrations up to 100 and 30 µM, respectively. It inhibits TRPC5 in a concentration-dependent manner in HEK293 cells when used at concentrations ranging from 1 to 100 µM. AC1903 (30 µM) inhibits angiotensin II-induced production of reactive oxygen species (ROS) in wild-type podocytes and podocytes expressing a mutant angiotensin II type 1 (AT1) receptor that cannot be inactivated and endocytosed. It also suppresses proteinuria as well as reduces pseudocyst formation and podocyte loss in an AT1 receptor transgenic rat model of kidney disease when administered at a dose of 50 mg/kg twice per day. In a model of hypertension-induced focal segmental glomerulosclerosis (FSGS) using Dahl salt-sensitive rats, AC1903 decreases the rate of proteinuria when administered at the beginning of a high-salt diet and prevents progression when administered one week following initiation of a high-salt diet.  

 

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SKU: 25324 - 5 mg Category:

Description

A TRPC5 inhibitor (IC50 = 14.7 µM); selective for TRPC5 over TRPC4 and TRPC6 at concentrations up to 100 and 30 µM, respectively; inhibits angiotensin II-induced production of ROS in wild-type podocytes and podocytes expressing a mutant AT1 receptor; suppresses proteinuria as well as reduces pseudocyst formation and podocyte loss in an AT1 receptor transgenic rat model of kidney disease at 50 mg/kg twice per day; decreases the rate of proteinuria and prevents progression in a Dahl salt-sensitive rat model of FSGS

Formal name: N-(2-furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine

Synonyms: 

Molecular weight: 303.4

CAS: 831234-13-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Kidney & Renal Disease

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