A fluorogenic substrate that can be cleaved by caspase-6 and related proteases including caspase-8

Ac-VEID-AMC – 10 mg

Brand:
Cayman
CAS:
219137-97-0
Storage:
-20
UN-No:
Non-Hazardous - /

Ac-VEID-AMC is a fluorogenic substrate based on the caspase-6 cleavage site in lamin A at amino acids VEID during apoptosis.{7213} It has also been reported to be cleaved by related proteases, including caspase-8.{25907} Caspase activity can be quantified by fluorescent detection of free AMC (also known as 7-amino-4-methylcoumarin), which is excited at 340-360 nm and emits at 440-460 nm.  

 

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Description

A fluorogenic substrate that can be cleaved by caspase-6 and related proteases including caspase-8

Formal name: N-acetyl-L-valyl-L-α-glutamyl-L-isoleucyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-α-asparagine

Synonyms:  Caspase-6 Substrate (Fluorogenic)|N-Acetyl-Val-Glu-Ile-Asp-7-amido-4-Methylcoumarin

Molecular weight: 673.7

CAS: 219137-97-0

Purity: ≥95%

Formulation: A crystalline solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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