A fluorogenic substrate whose peptides VDVAD have been shown to be a preferred cleavage site for caspase-2

Ac-VDVAD-AFC – 5 mg

Brand:
Cayman
CAS:
210344-94-8
Storage:
-20
UN-No:
Non-Hazardous - /

Ac-VDVAD-AFC is a fluorogenic substrate whose amino acids VDVAD have been shown to be a preferred cleavage site for caspase-2.{25871,7213} Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm. Increases in Ac-VDVAD-AFC cleavage have been reported to correlate with nitric oxide-induced activation of caspase-2 and subsequent apoptosis in human neuroblastoma lines.{25871}  

 

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Description

A fluorogenic substrate whose peptides VDVAD have been shown to be a preferred cleavage site for caspase-2

Formal name: N-acetyl-L-valyl-L-α-aspartyl-L-valyl-L-alanyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-L-α-asparagine

Synonyms:  Caspase-2 Substrate (Fluorogenic)|N-Acetyl-Val-Asp-Val-Ala-Asp-7-amino-4-Trifluoromethylcoumarin

Molecular weight: 770.7

CAS: 210344-94-8

Purity: ≥95%

Formulation: A crystalline solid

Application|Enzyme Activity||Application|Fluorescence||Product Type|Biochemicals|Labeling & Detection|Enzyme Substrates||Product Type|Biochemicals|Labeling & Detection|Fluorescent Probes||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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