A potent

Ac-DEVD-CHO – 500 µg

Brand:
Cayman
CAS:
184179-08-6
Storage:
-20
UN-No:
Non-Hazardous - /

Ac-DEVD-CHO is a potent inhibitor of the Group II caspases, caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively).{7777,7213} Notably, it also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively).{7777} Caspase inhibitors in the aldehyde form, like this compound, are typically reversible, whereas methyl ketone forms, like Ac-DEVD-CMK (Item No. 14465), are irreversible.{7777} Caspase inhibitors interfere with the initiation of apoptosis and have numerous possible clinical applications.{10070}  

 

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SKU: 10017 - 500 µg Category:

Description

A potent, reversible inhibitor of caspase-3 and caspase-7 (Kis = 0.23 and 1.6 nM, respectively); also inhibits other caspases (Kis = 18, 1710, 132, 205, 31, 0.92, 60, and 12 nM for caspases-1, -2, -4, -5, -6, -8, -9, and -10, respectively)

Formal name: N-acetyl-L-α-aspartyl-L-α-glutamyl-N-(2-carboxyl-1-formylethyl)-L-valinamide

Synonyms:  N-Ac-Asp-Glu-Val-Asp-CHO

Molecular weight: 502.5

CAS: 184179-08-6

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Small Molecule Inhibitors|Caspases||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Cell Death|Pyroptosis||Research Area|Cell Biology|Proteolysis|Cytosolic & Secreted Proteases

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