A PDGFR family kinase inhibitor (IC50s = 7.7

AC-710 – 5 mg

Brand:
Cayman
CAS:
1351522-04-7
Storage:
-20
UN-No:
Non-Hazardous - /

AC-710 is an inhibitor of PDGFR family kinases (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRβ, CSF1R, FLT3, and c-Kit, respectively).{53181} It is greater than 30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of five cytochrome P450 (CYP) enzymes (IC50s = >40 µM). AC-710 (30 mg/kg) inhibits CSF1R-dependent M-NFS-60 murine leukemia cell proliferation and reduces tumor volume in an FLT3 mutant MV4-11 leukemia mouse xenograft model.  

 

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SKU: 29498 - 5 mg Category:

Description

A PDGFR family kinase inhibitor (IC50s = 7.7, 10.5, 2, and 1.2 nM for PDGFRβ, CSF1R, FLT3, and c-Kit, respectively); >30-fold selective for PDGFR family kinases over a panel of 386 kinases, as well as over a panel of 5 CYP enzymes (IC50s = >40 µM); inhibits CSF1R-dependent M-NFS-60 murine leukemia cell proliferation and reduces tumor volume in an FLT3 mutant MV4-11 leukemia mouse xenograft model at 30 mg/kg

Formal name: N-[4-[[[[5-(1,1-dimethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide

Synonyms: 

Molecular weight: 562.7

CAS: 1351522-04-7

Purity: ≥98%

Formulation: A crystalline solid

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