A selective PAR2 agonist that stimulates cell proliferation

AC-55541 – 10 mg

Brand:
Cayman
CAS:
916170-19-9
Storage:
-20
UN-No:
Non-Hazardous - /

AC-55541 is a proteinase-activated receptor 2 (PAR2) agonist that displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation.{30968} It stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization in in vitro functional assays (pEC50s = 6.7, 5.9, and 6.6, respectively).{30968} Intrapaw administration of 3-10 mg/kg AC-55541 elicited pronociceptive activity in vivo.{30968}  

 

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Description

A selective PAR2 agonist that stimulates cell proliferation, phosphatidylinositol hydrolysis, and calcium mobilization in in vitro functional assays (pEC50s = 6.7, 5.9, and 6.6, respectively); elicits pronociceptive activity in vivo

Formal name: α-(benzoylamino)-3,4-dihydro-4-oxo-1-phthalazineacetic acid 2E-[1-(3-bromophenyl)ethylidene]hydrazide

Synonyms: 

Molecular weight: 518.4

CAS: 916170-19-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cell Biology|Cell Signaling|Calcium Mobilization

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