A SARM (Ki = 5.01 nM); an androgen receptor partial agonist (EC50 = 1.58 nM in a luciferase assay); selective for the androgen receptor over a panel of 47 additional human nuclear receptors at 10 µM; inhibits dihydroxytestosterone-induced proliferation of LNCaP prostate cancer cells at 0.1 and 1 µM; reduces plasma luteinizing hormone levels and increases levator ani muscle weight in castrated rats at 3

AC-262536 – 10 mg

Brand:
Cayman
CAS:
870888-46-3
Storage:
-20
UN-No:
Non-Hazardous - /

AC-262536 is a selective androgen receptor modulator (SARM; Ki = 5.01 nM).{59182} It is also a partial agonist of the androgen receptor (EC50 = 1.58 nM in a luciferase assay). AC-262536 is selective for the androgen receptor over a panel of 47 additional human nuclear receptors at 10 µM. It inhibits dihydroxytestosterone-induced proliferation of LNCaP prostate cancer cells when used at concentrations of 0.1 and 1 µM. AC-262536 (3, 10, and 30 mg/kg) reduces plasma luteinizing hormone levels and increases levator ani muscle weight, a marker of anabolic activity, in castrated rats. It exhibits smaller increases in prostate gland and seminal vesicle weight, markers of androgenic activity, compared with testosterone in the same model.  

 

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SKU: 31598 - 10 mg Category:

Description

A SARM (Ki = 5.01 nM); an androgen receptor partial agonist (EC50 = 1.58 nM in a luciferase assay); selective for the androgen receptor over a panel of 47 additional human nuclear receptors at 10 µM; inhibits dihydroxytestosterone-induced proliferation of LNCaP prostate cancer cells at 0.1 and 1 µM; reduces plasma luteinizing hormone levels and increases levator ani muscle weight in castrated rats at 3, 10, and 30 mg/kg; exhibits smaller increases in prostate gland and seminal vesicle weight compared with testosterone in the same model

Formal name: 4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-naphthalenecarbonitrile

Synonyms: 

Molecular weight: 278.4

CAS: 870888-46-3

Purity: ≥98%

Formulation: A solid

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