An orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM

ABT-888 (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
912445-05-7
Storage:
-20
UN-No:
Non-Hazardous - /

Poly(ADP-ribose) polymerases (PARPs) have diverse roles in cellular processes, including DNA repair and apoptosis.{22577,20553} ABT-888 is an orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively).{24824} It enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation.{24828,24825} ABT-888 also acts synergistically with chemotherapies to increase the lethal effects of radiation in cancer cells.{24827,24826}  

 

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SKU: 11505 - 1 mg Category:

Description

An orally bioavailable inhibitor of PARP1 and PARP2 (Kis = 5.2 and 2.9 nM, respectively); enhances apoptosis and autophagy in response to treatments that cause DNA breaks, including radiation and DNA alkylation

Formal name: 2-[(2R)-2-methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide, dihydrochloride

Synonyms:  Veliparib

Molecular weight: 317.2

CAS: 912445-05-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|DNA Damage and Repair|PARP||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Cell Biology|Endomembrane System & Vesicular Trafficking|Autophagy

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