A tubulin polymerization inhibitor; binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM); inhibits tubulin polymerization in a concentration-dependent manner; inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml); induces tumor regression in NB-1382 neuroblastoma

ABT-751 – 50 mg

Brand:
Cayman
CAS:
141430-65-1
Storage:
-20
UN-No:
Non-Hazardous - /

ABT-751 is a tubulin polymerization inhibitor that binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM).{36969} It inhibits tubulin polymerization in a concentration-dependent manner and inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml). ABT-751 (100 mg/kg, p.o.) induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models.{36968} It also induces tumor endothelial cell retraction and reduces tumor perfusion, but not muscle perfusion, in a 9L rat glioma subcutaneous tumor model.{36970}  

 

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Description

A tubulin polymerization inhibitor; binds to the colchicine binding site on β-tubulin (Ki = 3.3 μM); inhibits tubulin polymerization in a concentration-dependent manner; inhibits growth of 26 human tumor cell lines (IC50s = 0.06-0.08 μg/ml); induces tumor regression in NB-1382 neuroblastoma, IRS56 rhabdomyosarcoma, and KT-6 Wilms mouse xenograft models at 100 mg/kg; induces tumor endothelial cell retraction and reduces tumor perfusion in a 9L rat glioma subcutaneous tumor model

Formal name: N-[2-[(4-hydroxyphenyl)amino]-3-pyridinyl]-4-methoxy-benzenesulfonamide

Synonyms: 

Molecular weight: 371.4

CAS: 141430-65-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer||Research Area|Cell Biology|Cytoskeleton & Motor Proteins

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