Description
A dopamine D4 receptor agonist (EC50 = 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5); selective for dopamine D4 over D2 receptors at 10 μM; induces penile erections in 77% of male rats at 0.03 μmol/kg; decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats at 0.04 mg/kg; decreases hyperactivity and exploratory behavior in the open field test in an adolescent SHR model of ADHD at 0.16 and 0.64 mg/kg
Formal name: 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole, trihydrochloride
Synonyms:
Molecular weight: 402.8
CAS: 587870-77-7
Purity: ≥98%
Formulation: A solid
