A dopamine D4 receptor agonist (EC50 = 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5); selective for dopamine D4 over D2 receptors at 10 μM; induces penile erections in 77% of male rats at 0.03 μmol/kg; decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats at 0.04 mg/kg; decreases hyperactivity and exploratory behavior in the open field test in an adolescent SHR model of ADHD at 0.16 and 0.64 mg/kg

ABT-724 (hydrochloride) – 10 mg

Brand:
Cayman
CAS:
587870-77-7
Storage:
-20
UN-No:
Non-Hazardous - /

ABT-724 is a dopamine D4 receptor agonist with an EC50 value of 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5.{45687} It is selective for dopamine D4 over D2 receptors at 10 μM. ABT-724 (0.03 μmol/kg) induces penile erections in 77% of male rats. It decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats when administered at a dose of 0.04 mg/kg.{45688} ABT-724 (0.16 and 0.64 mg/kg) decreases hyperactivity and exploratory behavior in the open field test in an adolescent spontaneously hypertensive rat (SHR) model of attention-deficit hyperactivity disorder (ADHD).{45689}  

 

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Description

A dopamine D4 receptor agonist (EC50 = 12.4 nM in a FLIPR calcium flux assay using HEK293 cells expressing the human D4.4 receptor and Gαqo5); selective for dopamine D4 over D2 receptors at 10 μM; induces penile erections in 77% of male rats at 0.03 μmol/kg; decreases mounting frequency and ejaculation latency and increases ejaculation frequency and copulatory efficacy in male rats at 0.04 mg/kg; decreases hyperactivity and exploratory behavior in the open field test in an adolescent SHR model of ADHD at 0.16 and 0.64 mg/kg

Formal name: 2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-benzimidazole, trihydrochloride

Synonyms: 

Molecular weight: 402.8

CAS: 587870-77-7

Purity: ≥98%

Formulation: A solid

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