A covalent inhibitor of PME-1 (IC50 = 4.2 nM); selectively inhibits PME-1 over 50 other serine hydrolases in MDA-MB-231 and HEK293T cell lysates at 10 μM; decreases proliferation of Ishikawa cells and migration of ECC-1 endometrial carcinoma cells when used at a concentration of 50 nM

ABL 127 – 1 mg

Brand:
Cayman
CAS:
1073529-41-5
Storage:
-20
UN-No:
Non-Hazardous - /

ABL 127 is a covalent aza-β-lactam inhibitor of protein phosphatase methylesterase-1 (PME-1; IC50 = 4.2 nM).{19272} It selectively inhibits PME-1 over 50 other serine hydrolases in MDA-MB-231 and HEK293T cell lysates at 10 μM. ABL 127 decreases proliferation of Ishikawa cells and migration of ECC-1 endometrial carcinoma cells when used at a concentration of 50 nM.{42730}  

 

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SKU: 10833 - 1 mg Category:

Description

A covalent inhibitor of PME-1 (IC50 = 4.2 nM); selectively inhibits PME-1 over 50 other serine hydrolases in MDA-MB-231 and HEK293T cell lysates at 10 μM; decreases proliferation of Ishikawa cells and migration of ECC-1 endometrial carcinoma cells when used at a concentration of 50 nM,

Formal name: (3R)-3-cyclopentyl-4-oxo-3-phenyl-1,2-diazetidine-1,2-dicarboxylic acid, 1,2-dimethyl ester

Synonyms: 

Molecular weight: 332.4

CAS: 1073529-41-5

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Migration & Metastasis

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