A diterpene with enzyme inhibitory

Abietic Acid – 10 g

Brand:
Cayman
CAS:
514-10-3
Storage:
-20
UN-No:
Excepted Quantity - 3077 / 9

Abietic acid is an abietane diterpene originally isolated from wood resin that has diverse biological activities, including enzyme inhibitory, antiproliferative, antibacterial, and anti-obesity properties.{42172,42173,42174,42175,42176,42177} It inhibits soybean 5-lipoxygenase (5-LO) and rat prostate testosterone 5α-reductase in cell-free assays (IC50s = 29.5 and 56 μM, respectively).{42173,42174} Abietic acid selectively inhibits proliferation of HeLa cervical cancer cells over noncancerous Vero cells (IC50s = 15 and 53 μM, respectively) and inhibits the growth of S. epidermidis, P. acnes, and S. mitis bacteria (MICs = 8, 4, and 16 μg/ml, respectively).{42175,42176} It induces expression of fatty acid binding protein 2 (FABP2; Item No. 10009548) and lipoprotein lipase (LPL) in differentiated 3T3-L1 mouse adipocytes when used at a concentration of 25 μM.{42178} Abietic acid (40 mg/kg per day) also decreases body and adipose tissue weight in mice fed a high-fat diet.{42177}  

 

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SKU: 24927 - 10 g Category:

Description

A diterpene with enzyme inhibitory, antiproliferative, antibacterial, and anti-obesity biological properties; inhibits soybean 5-LO and rat prostate testosterone 5α-reductase in cell-free assays (IC50s = 29.5 and 56 μM, respectively); selectively inhibits proliferation of HeLa cervical cancer cells over noncancerous Vero cells (IC50s = 15 and 53 μM, respectively); inhibits growth of S. epidermidis, P. acnes, and S. mitis bacteria (MICs = 8, 4, and 16 μg/ml, respectively); induces FABP2 and LPL expression in differentiated 3T3-L1 mouse adipocytes at 25 μM; decreases body and adipose tissue weight in mice fed a high-fat diet at 40 mg/kg per day

Formal name: (1R,4aR,4bR,10aR)-1,2,3,4,4a,4b,5,6,10,10a-decahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenecarboxylic acid

Synonyms:  (-)-Abietic Acid,|NSC 25149|Sylvic Acid

Molecular weight: 302.5

CAS: 514-10-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors|Lipoxygenases||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Leukotrienes||Research Area|Infectious Disease|Bacterial Diseases

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