Description
An inhibitor of arginase types I and II; inhibits arginase activity in homogenized opossum brain, rectum, and internal anal sphincter (Kis = 0.018, 0.026, and 0.05 µM, respectively), indicating arginase II inhibition, and in the liver (Ki = 0.19 µM), indicating arginase I inhibition; inhibits arginase II in a classical, competitive manner at a pH of 7.5 and in a slow-binding manner at a pH of 9.5 (Kis = 0.25 and 0.31 µM, respectively); increases the duration, but not the rigidity, of penile tumescence in male rabbits at an intracavernosal dose of 150 µg and increases vaginal blood flow in female rabbits; decreases arginase activity in male rat penis and increases intracavernosal pressure in aged rats at ~400 µg/day for 25 days via the drinking water; prevents increases in IL-8 levels, neutrophil and goblet cell numbers, and development of right ventricular hypertrophy, as well as reduces airway fibrosis in a guinea pig model of LPS-induced COPD
Formal name: 6-borono-L-norleucine
Synonyms: Amino-2-Borono-6-Hexanoic Acid
Molecular weight: 175
CAS: 222638-65-5
Purity: ≥90%
Formulation: A crystalline solid
Product Type|Biochemicals|Small Molecule Inhibitors|Amino Acid Turnover||Research Area|Cardiovascular System|Heart|Myocardial Hypertrophy||Research Area|Cardiovascular System|Vasculature||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|COPD/Emphysema
