An adenosine A3 receptor agonist (Ki = 430.5 nM for the human receptor expressed in CHO cells); inhibits LPS-induced TNF-α production in primary cultured human lung macrophages (pD2 = 6.9); increases contraction of isolated guinea pig trachea at 0.1 μM and increases bronchoconstriction in vivo at 3 μg/kg in a guinea pig model of ovalbumin-sensitized asthma; radiolabeled form binds to rat adenosine A1 and A3 receptors (Kds = 3.42 and 1.48 nM in COS-7 and CHO cells

AB-MECA – 1 mg

Brand:
Cayman
CAS:
152918-26-8
Storage:
-20
UN-No:
Non-Hazardous - /

AB-MECA is an adenosine A3 receptor agonist (Ki = 430.5 nM for the human receptor expressed in CHO cells).{45426} It inhibits LPS-induced TNF-α production in primary cultured human lung macrophages (pD2 = 6.9).{45427} AB-MECA increases contraction of isolated guinea pig trachea ex vivo when used at a concentration of 0.1 μM and increases bronchoconstriction in vivo when administered at a dose of 3 μg/kg in a guinea pig model of ovalbumin-sensitized asthma.{45428} A radiolabeled form of AB-MECA has been used for radioligand binding assays and binds to rat adenosine A1 and A3 receptors (Kds = 3.42 and 1.48 nM in COS-7 and CHO cells, respectively) and canine adenosine A2a receptors (Kd = 25.1 nM in COS-7 cells).{45429}  

 

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SKU: 28415 - 1 mg Category:

Description

An adenosine A3 receptor agonist (Ki = 430.5 nM for the human receptor expressed in CHO cells); inhibits LPS-induced TNF-α production in primary cultured human lung macrophages (pD2 = 6.9); increases contraction of isolated guinea pig trachea at 0.1 μM and increases bronchoconstriction in vivo at 3 μg/kg in a guinea pig model of ovalbumin-sensitized asthma; radiolabeled form binds to rat adenosine A1 and A3 receptors (Kds = 3.42 and 1.48 nM in COS-7 and CHO cells, respectively) and canine adenosine A2a receptors (Kd = 25.1 nM in COS-7)

Formal name: 1-[6-[[(4-aminophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl-β-D-ribofuranuronamide

Synonyms: 

Molecular weight: 399.4

CAS: 152918-26-8

Purity: ≥98%

Formulation: A crystalline solid

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