A potent

A-967079 – 50 mg

Brand:
Cayman
CAS:
1170613-55-4
Storage:
-20
UN-No:
Non-Hazardous - /

The transient receptor potential ankyrin 1 (TRPA1) ion channel integrates the nociception and transmission of diverse potentially damaging and noxious stimuli, including cold, electrophilic compounds, divalent cations, and mechanical stimulation.{24761,24757} A-967079 is a potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively.{24758} It attenuates cold allodynia following nerve injury without producing locomotor or cardiovascular side effects.{24758} A-967079 also suppresses neuronal activity in response to mechanical stimulation and diminishes postoperative pain due to mechanical stimuli.{24759,24757}  

 

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Description

A potent, selective, and bioavailable inhibitor of the TRPA1 channel, with IC50 values of 67 and 289 nM for the human and rat isoforms, respectively; attenuates cold allodynia following nerve injury and suppresses neuronal activity in response to mechanical stimulation

Formal name: (1E,3E)-1-(4-fluorophenyl)-2-methyl-1-penten-3-one oxime

Synonyms: 

Molecular weight: 207.3

CAS: 1170613-55-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Neuroscience|Pain Research

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