A dual inhibitor of PARP1 and PARP2 (Kis = 1 and 1.5 nM

A-966492 – 25 mg

Brand:
Cayman
CAS:
934162-61-5
Storage:
-20
UN-No:
- 3077 / 9

A-966492 is a dual inhibitor of poly(ADP-ribose) polymerase 1 (PARP1) and PARP2 (Kis = 1 and 1.5 nM, respectively).{54041} It reduces tumor growth by 46 and 92% in an MX-1 mouse xenograft model when administered at doses of 100 and 200 mg/kg per day, respectively.{54041} A-966492 also reduces tumor growth in a B16/F10 murine melanoma model when administered in combination with temozolomide (Item No. 14163).  

 

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SKU: 26378 - 25 mg Category:

Description

A dual inhibitor of PARP1 and PARP2 (Kis = 1 and 1.5 nM, respectively); reduces tumor growth by 46 and 92% in an MX-1 mouse xenograft model at 100 and 200 mg/kg per day, respectively; reduces tumor growth in a B16/F10 murine melanoma model in combination with temozolomide

Formal name: 2-[2-fluoro-4-[(2S)-2-pyrrolidinyl]phenyl]-1H-benzimidazole-7-carboxamide

Synonyms: 

Molecular weight: 324.4

CAS: 934162-61-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors|DNA Repair Enzymes||Research Area|Cancer|DNA Damage and Repair|PARP

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