A selective α1A-adrenergic receptor agonist that is at least 35-fold more potent at α1A receptor sites than at α1B or α1D; increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro with 330-fold more potency compared to activation by phenylephrine

A-61603 – 10 mg

Brand:
Cayman
CAS:
107756-30-9
Storage:
-20
UN-No:
Non-Hazardous - /

The α1-adrenergic receptors are Gq protein-coupled receptors that play a key role in the modulation of sympathetic nervous system activity and are the site of action for therapeutic agents, such as antihypertensive drugs. A-61603 is a selective α1A-adrenergic receptor agonist that is at least 35-fold more potent at α1A receptor sites than at α1B or α1D.{28349} Activation of the α1A-adrenergic receptor by A-61603 has been reported to increase the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro (EC50 = 6.9 nM) much more potently than activation by phenylephrine (Item No. 17205; EC50 = 2.3 µM).{28350}  

 

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Description

A selective α1A-adrenergic receptor agonist that is at least 35-fold more potent at α1A receptor sites than at α1B or α1D; increases the frequency of spontaneous Ca2+ transients in rat ventricular myocytes in vitro with 330-fold more potency compared to activation by phenylephrine

Formal name: N-[5-(4,5-dihydro-1H-imidazol-2-yl)-5,6,7,8-tetrahydro-2-hydroxy-1-naphthalenyl]-methanesulfonamide, monohydrobromide

Synonyms: 

Molecular weight: 390.3

CAS: 107756-30-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Heart

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