Description
A P2X3 and P2X2/3 receptor antagonist (Kis = 22-92 nM in a calcium influx assay); selective over other purinergic and neurotransmitter receptors, ion channels, and enzymes (IC50s = >10 µM); reduces thermal hyperalgesia induced by complete Freund’s adjuvant in rats (ED50 = 30 µmol/kg, s.c.) and nociceptive responses to chemically-induced pain; chronic administration reduces early, but not late, phase pain in a mouse model of bone cancer; does not readily cross the blood-brain barrier and reduces pain responses when applied topically,
Formal name: 5-[[[(3-phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid
Synonyms:
Molecular weight: 565.6
CAS: 475205-49-3
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Immunology & Inflammation||Research Area|Neuroscience|Pain Research
