A selective Mcl-1 inhibitor (Ki = 0.43 nM; IC50 = 26.2 nM); disrupts the interaction between Mcl-1 and pro-apoptotic BIM

A-1210477 – 10 mg

Brand:
Cayman
CAS:
1668553-26-1
Storage:
-20
UN-No:
De Minimis - 3077 / 9

A-1210477 is an inhibitor of the antiapoptotic Bcl-2 family protein myeloid cell leukemia-1 (Mcl-1; Ki = 0.43 nM and IC50 = 26.2 nM) that demonstrates >100-fold selectivity over other Bcl-2 family members (Kis > 0.66 µM for Bcl-2, Bcl-XL, Bcl-W, and Bfl-1).{32901,32902,32900} It has been shown to disrupt the interaction between Mcl-1 and pro-apoptotic BIM, inducing the hallmarks of apoptosis in Mcl-1-dependent multiple myeloma and non-small cell lung cancer cell lines.{32901,32900}  

 

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Description

A selective Mcl-1 inhibitor (Ki = 0.43 nM; IC50 = 26.2 nM); disrupts the interaction between Mcl-1 and pro-apoptotic BIM, inducing the hallmarks of apoptosis in Mcl-1-dependent multiple myeloma and non-small cell lung cancer cell lines

Formal name: 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]-1H-indole-2-carboxylic acid

Synonyms: 

Molecular weight: 850

CAS: 1668553-26-1

Purity: ≥98%

Formulation: A crystalline solid

Application||Product Type|Biochemicals||Research Area|Cancer|Cell Death|Apoptosis

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