A Bcl-xL inhibitor (Ki = is = 80 and 16 nM

A-1155463 – 1 mg

Brand:
Cayman
CAS:
1235034-55-5
Storage:
-20
UN-No:
De Minimis - 3077 / 9

A-1155463 is an inhibitor of Bcl-xL (Ki = is = 80 and 16 nM, respectively). A-1155463 inhibits the growth of H146 small cell lung cancer cells (EC50 = 65 nM). In vivo, A-1155463 (5 mg/kg, i.p.) reduces tumor volume in an H146 mouse xenograft model. A-1155463 also induces premature apoptosis in influenza A-infected cells (EC50 = <10 nM).{46183}  

 

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SKU: 27369 - 1 mg Category:

Description

A Bcl-xL inhibitor (Ki = is = 80 and 16 nM, respectively); inhibits the growth of H146 small cell lung cancer cells (EC50 = 65 nM); reduces tumor volume in an H146 mouse xenograft model at 5 mg/kg; induces premature apoptosis in influenza A-infected cells (EC50 = <10 nM),

Formal name: 2-[8-[(2-benzothiazolylamino)carbonyl]-3,4-dihydro-2(1H)-isoquinolinyl]-5-[3-[4-[3-(dimethylamino)-1-propyn-1-yl]-2-fluorophenoxy]propyl]-4-thiazolecarboxylic acid

Synonyms: 

Molecular weight: 669.8

CAS: 1235034-55-5

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Influenza

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