An RBP4 antagonist (Ki = 8.3 nM for disruption of RBP4 binding to transthyretin); selective for RBP4 over CRBP1 (IC50s = 0.09 and >30 µM

A-1120 – 10 mg

Brand:
Cayman
CAS:
1152782-19-8
Storage:
-20
UN-No:
Non-Hazardous - /

A-1120 is a non-retinoid retinol binding protein 4 (RBP4) antagonist (Ki = 8.3 nM for disruption of RBP4 binding to transthyretin).{58011} It is selective for RBP4 over cellular retinol binding protein 1 (CRBP1; IC50s = 0.09 and >30 µM, respectively, in radioligand binding assays), as well as a panel of G protein-coupled receptors, kinases, and enzymes. A-1120 (30 mg/kg) reduces serum levels of RBP4 and retinol in mice. It also inhibits retinal bisretinoid accumulation in the Abca4-/- mouse model of enhanced retinal lipofuscinogenesis-induced macular degeneration.{58012}  

 

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SKU: 30921 - 10 mg Category:

Description

An RBP4 antagonist (Ki = 8.3 nM for disruption of RBP4 binding to transthyretin); selective for RBP4 over CRBP1 (IC50s = 0.09 and >30 µM, respectively, in radioligand binding assays), as well as a panel of G protein-coupled receptors, kinases, and enzymes; reduces serum levels of RBP4 and retinol levels in mice at 30 mg/kg; inhibits retinal bisretinoid accumulation in the Abca4-/- mouse model of enhanced retinal lipofuscinogenesis-induced macular degeneration

Formal name: 2-[[[4-[2-(trifluoromethyl)phenyl]-1-piperidinyl]carbonyl]amino]-benzoic acid

Synonyms: 

Molecular weight: 392.4

CAS: 1152782-19-8

Purity: ≥95%

Formulation: A crystalline solid

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