α-ESA methyl ester is a neutral

9(Z),11(E),13(E)-Octadecatrienoic Acid methyl ester – 10 mg

Brand:
Cayman
CAS:
4175-47-7
Storage:
-80
UN-No:
De Minimis - 1170 / 3

9Z,11E,13E-octadecatrienoic acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil.{14176} α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats.{14175} It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ.{14176} In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM.{14175} It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes.{14174} α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.  

 

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SKU: 10008333 - 10 mg Category:

Description

α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

Formal name: 9Z,11E,13E-octadecatrienoic acid, methyl ester

Synonyms:  Methyl α-eleostearate|α-ESA methyl ester

Molecular weight: 292.5

CAS: 4175-47-7

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Fatty Esters/Ethers||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53||Research Area|Lipid Biochemistry|Fatty Acids

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