Description
α-ESA is a conjugated PUFA commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil.{14176} α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats.{14175} It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ.{14176} In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM.{14175} It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes.{14174}
Formal name: 9Z,11E,13E-octadecatrienoic acid
Synonyms: LAF 237|α-Eleostearic Acid|α-ESA
Molecular weight: 278.4
CAS: 506-23-0
Purity: ≥95%
Formulation: A solution in methanol
Product Type|Biochemicals|Lipids|Fatty Acids||Product Type|Biochemicals|Lipids|Octadecanoids||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Cancer|Transcription Factors|p53||Research Area|Lipid Biochemistry|Fatty Acids
