Description
An isomer of linoleic acid; binds to PPARα (IC50 = 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα at 100 µM; inhibits TNF-α-induced GLUT4 expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes; reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration in ob/ob mice; increases body weight gain and body fat in weanling mice
Formal name: (9Z,11E)-9,11-octadecadienoic acid, monosodium salt
Synonyms: cis-9,trans-11-Conjugated Linoleic Acid|9(Z),11(E)-CLA
Molecular weight: 302.4
CAS: 756499-04-4
Purity: ≥98%
Formulation: A solid