An isomer of linoleic acid; binds to PPARα (IC50 = 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα at 100 µM; inhibits TNF-α-induced GLUT4 expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes; reduces serum fasting glucose

9(Z),11(E)-Conjugated Linoleic Acid (sodium salt) – 10 mg

Brand:
Cayman
CAS:
756499-04-4
Storage:
-20
UN-No:
Non-Hazardous - /

9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) that has been found in beef and milk fat.{6849} It binds to peroxisome proliferator-activated receptor α (PPARα; IC50 = 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 µM.{15462} 9(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-induced GLUT4 expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.{59110} Dietary administration of 9(Z)11(E)-conjugated linoleic acid reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration in ob/ob mice. It also increases body weight gain and body fat in weanling mice.{10568} [Matreya, LLC. Catalog No. 1278]  

 

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Description

An isomer of linoleic acid; binds to PPARα (IC50 = 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα at 100 µM; inhibits TNF-α-induced GLUT4 expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes; reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration in ob/ob mice; increases body weight gain and body fat in weanling mice

Formal name: (9Z,11E)-9,11-octadecadienoic acid, monosodium salt

Synonyms:  cis-9,trans-11-Conjugated Linoleic Acid|9(Z),11(E)-CLA

Molecular weight: 302.4

CAS: 756499-04-4

Purity: ≥98%

Formulation: A solid

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