An isomer of linoleic acid; binds to PPARα (IC50 = 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα at 100 µM; inhibits TNF-α-induced GLUT4 expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes; reduces serum fasting glucose

9(Z),11(E)-Conjugated Linoleic Acid – 10 mg

Brand:
Cayman
CAS:
2540-56-9
Storage:
-20
UN-No:
De Minimis - 1170 / 3

9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) that has been found in beef and milk fat.{6849} It binds to peroxisome proliferator-activated receptor α (PPARα; IC50 = 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 µM.{15462} 9(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-induced GLUT4 expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.{59110} Dietary administration of 9(Z)11(E)-conjugated linoleic acid reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration in ob/ob mice. It also increases body weight gain and body fat in weanling mice.{10568}  

 

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SKU: 90140 - 10 mg Category:

Description

An isomer of linoleic acid; binds to PPARα (IC50 = 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα at 100 µM; inhibits TNF-α-induced GLUT4 expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes; reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration in ob/ob mice; increases body weight gain and body fat in weanling mice

Formal name: 9Z,11E-octadecadienoic acid

Synonyms:  cis-9,trans-11-Conjugated Linoleic Acid|9Z,11E-CLA

Molecular weight: 280.5

CAS: 2540-56-9

Purity: ≥98%

Formulation: A solution in ethanol

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