(9Z)-Tricosene is a pheromone released by insects, including D. melanogaster, M. domestica (house fly), and A. mellifera L. (honey bee).{34326,34327,34328} In Drosophila, it induces aggregation behavior and is an oviposition guidance cue for females.{34326} Due to its aggregation-inducing activity, it is used as a bait pesticide to attract insects to traps.{34325} The mechanism of action in Drosophila is the activation of antennal basiconic Or7a receptors.{34326} It is also highly produced by honey bees during the waggle dance, which is a complex communication process used to alert nest-mates of the location and profitability of a food source.{34327} When injected into a hive, (9Z)-tricosene induced foraging behavior.
An insect pheromone used in pesticides; activates antennal basiconic Or7a receptors in Drosophila; produced by honey bees to communicate information about food sources
Formal name: 9Z-tricosene
Synonyms: cis-9-Tricosene|Muscalure
Molecular weight: 322.6
CAS: 27519-02-4
Purity: ≥90%
Formulation: A liquid
Product Type|Biochemicals|Lipids|Hydrocarbons||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Reproductive Biology
The maintenance of embryonic stem cells in culture typically requires feeder cells and various exogenous factors found in serum. Murine embryonic stem (mES) cells can be maintained in the absence of feeder cells and serum but require the leukemia inhibitor factor (LIF) and bone morphogenic protein (BMP) to prevent differentiation and promote self-renewal. SC-1 is a small molecule activator of stem cell renewal that allows the propagation of OG2 mES cells for at least 10 passages in an undifferentiated state.{14533} The activity of SC-1 is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.{14533} Inhibition of RasGAP increases Ras signaling via the PI3-kinase pathway which promotes self-renewal, whereas inhibition of ERK blocks differentiation.
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