An oxylipin with diverse biological activities; has been found in various plants; is produced in human eosinophils in a 15-lipoxygenase-dependent

9(S),12(S),13(S)-TriHOME – 100 µg

Brand:
Cayman
CAS:
97134-11-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.{48960,48961,48962,16197} It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.{48960,45735} 9(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50 = 28.7 µg/ml).{48961} It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50 = 40.95 µM).{48962} In vivo, 9(S),12(S),13(S)-TriHOME (1 g/animal) enhances the antiviral IgA and IgG antibody responses induced by a nasal influenza hemagglutinin (HA) vaccine by 5.2- and 2-fold, respectively, in mice.{16197}  

 

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SKU: 10005143 - 100 µg Category:

Description

An oxylipin with diverse biological activities; has been found in various plants; is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner; inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50 = 28.7 µg/ml); inhibits LPS-induced NO production in BV-2 microglia (IC50 = 40.95 µM); enhances the antiviral IgA and IgG antibody responses induced by a nasal influenza HA vaccine in mice at 1g/animal

Formal name: 9S,12S,13S-trihydroxy-10E-octadecenoic acid

Synonyms:  (–)-Pinellic Acid|9S,12S,13S-Pinellic Acid

Molecular weight: 330.5

CAS: 97134-11-7

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Octadecanoids||Research Area|Cell Biology|Cell Signaling|Nitric Oxide Signaling||Research Area|Immunology & Inflammation|Allergy||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Lipid Biochemistry|Lipoxygenase Pathways||Research Area|Neuroscience

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